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The life cycle of Leishmania species.
The life cycle of Leishmania species. Sandflies inject infective promastigotes into a susceptible mammal during feeding. Promastigotes are phagocytosed by resident phagocytes, transform into tissue-stage amastigotes, and multiply within these cells through simple division. The parasite continues to infect phagocytic cells either at the site of cutaneous infection or in secondary lymphoid organs, with eventual parasitemia. Sandflies become infected through feeding on a host either with an active skin lesion in CL or with parasitemia in VL. Parasites convert to promastigotes within the sandfly midgut. Promastigotes migrate from the midgut and transform into highly infectious metacyclic promastigotes. Kevin J. Esch, and Christine A. Petersen Clin. Microbiol. Rev. 2013; doi: /CMR
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