Toxoplasma+trichomonas

Toxoplasma gondii Trichomonas vaginalis Dr Kamran Afzal Classified Microbiologist

What is Toxoplasma gondii ? ,[object Object],[object Object],[object Object],[object Object]

Transmission ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factors determining infection prevalence ,[object Object],[object Object],[object Object],[object Object]

Oocyst ,[object Object],[object Object]

Latent Bradyzoite cysts confer life-long infection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tachyzoite – Bradyzoite conversion

Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Congenital toxoplasmosis ,[object Object],[object Object],[object Object],[object Object]

Does T. gondii affect people? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Laboratory Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Serology workup Antibody testing Antibody testing may be Followed by prenatal PCR or by CT or MRI scans

Treatment ,[object Object],[object Object],[object Object],[object Object]

Prevention and Control ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Trichomonas vaginalis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prevalence ,[object Object],[object Object],[object Object],[object Object]

Trichomonas vaginalis Life Cycle

Why is it Pathogenic in Females? ,[object Object],[object Object],[object Object]

Three main types of vaginitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Vaginitis Differentiation Normal Trichomoniasis Candidiasis Bacterial Vaginosis Symptom presentation Itch, discharge, 50% asymptomatic Itch, discomfort, dysuria, thick discharge Odor, discharge, itch Vaginal discharge Clear to white Frothy, gray or yellow-green; malodorous Thick, clumpy, white “cottage cheese” Homogenous, adherent, thin, milky white; malodorous “foul fishy” Clinical findings Cervical petechiae “strawberry cervix” Inflammation and erythema Vaginal pH 3.8 - 4.2 > 4.5 Usually < 4.5 > 4.5 KOH “whiff” test Negative Often positive Negative Positive NaCl wet mount Lacto-bacilli Motile flagellated protozoa, many WBCs Few WBCs Clue cells ( > 20%), no/few WBCs KOH wet mount Pseudohyphae or spores if non- albicans species

What is Trichomoniasis? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical Diagnosis ,[object Object]

Laboratory Diagnosis ,[object Object],[object Object],[object Object],[object Object]

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Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prevention ,[object Object],[object Object],[object Object]

Toxoplasma+trichomonas

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